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International Journal of Pharmacy & Biomedical Research (IJPBR)
Year : 2021, Volume : 8, Issue : 2
First page : (12) Last page : (17)
Article doi: http://dx.doi.org/10.18782/2394-3726.1109

Anti-Edema Activity of Sida rhombifolia in Albino Wistar Rats

 

N. R. Livingston Raja*, V. Babiya, A. Poojah, Raijimol Jose, M. Soundhararajan
Department of Pharmacology, S A Raja Pharmacy College, Vadakanguam, Tamilnadu – 627 116
*Corresponding Author E-mail: liviverna2016@gmail.com
Received: 9.02.2021 | Revised: 13.03.2021 | Accepted: 19.03.2021 


ABSTRACT

Diuretics increase the excretion of water from bodied which induce negative fluid balance and are useful in the treatment of diseases like edema and hypertension. In the present study “Anti-edema activity of ethanolic extract of Sida rhombifolia linn was assessed for diuretic activity of in male albino rats. Preliminary phytochemical studies carried out in the selected S. rhombifolia plant extract which indicated the presence of flavonoids, saponins, carotinoids, glycosides, tannins, phenols and carbohydrates. Acute toxicity studies of the ethanolic extract of the S. rhombifolia did not show any signs of harmfulness up to 2 g/kg body weight. Since there was no mortality, morbidity observed at a higher level dose. In this study 100 and 200 mg/kg doses were selected for assessment of diuretic activity. The diuretic activity of the extract was done by quantification of urine volume and electrolyte concentration. Different doses S. rhombifolia (100 mg/kg and 200 mg/kg) were administered orally to hydrated rats and the urine output was measured every hour, up to 3 hours. Furosemide (20 mg/kg) was used as standard drug, while normal saline (10ml/kg) was used as control. The treatment of S. rhombifolia at varying doses (100 mg/kg and 200 mg/kg) significantly (P>0.001) increases the urine output (5.25ml, 11.13ml) and the excretion of Na+ (301.16 PPM, 371.49 PPM). Likewise, a potassium-sparing effect at 24.06 PPM and 22.08 PPM was observed. Based on the remarks, the study can be concluded that S. rhombifolia extracts has diuretic property in a dose-dependent manner.

Keywords: Diuretics, S. rhombifolia, Glycosides, Tannins, Furosemide mortality, Morbidity.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2394-3726

Cite this article: Raja, N. R.L., Babiya, V., Poojah, A., Jose, R., & Soundhararajan, M. (2021). Anti-Edema Activity of Sida rhombifolia in albino wistar rats, Int. J. Phar.& Biomedi. Rese. 8(2), 12-17. doi: http://dx.doi.org/10.18782/2394-3726.1109