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International Journal of Pharmacy & Biomedical Research (IJPBR)
Year : 2020, Volume : 7, Issue : 4
First page : (6) Last page : (16)
Article doi: http://dx.doi.org/10.18782/2394-3726.1099

Role of Micro RNA in Therapy of Atherosclerosis and Skin Fibrosis: A Review

Anusree S.1*, Silvia Navis2 and Prasobh G. R.3
1Assistant Professor, Sreekrishna College of Pharmacy and Research Centre, Kerala
2HOD Department of Pharmacology, Sreekrishna College of Pharmacy and Research Centre, Kerala
3Principal, Sreekrishna College of Pharmacy and Research Centre, Kerala
*Corresponding Author E-mail: anusarath07@gmail.com
Received: 15.06.2020  |  Revised: 22.07.2020   |  Accepted: 25.07.2020 


ABSTRACT

MiRNAs are highly conserved class of small (19-25 nucleotides), non-coding RNAs, which regulate post-transcriptional gene expression by binding to target mRNAs and result in gene silencing. In the genome, miRNAs can be found situated in the exons of non-coding genes, introns of coding and non-coding genes and the intragenic regions. Small interfering RNAs are approximately 22 nucleotides in length and mediate RNA interference (RNAi). miRNAs control endothelial cell, vascular smooth muscle cell and macrophage functions, and thereby regulate the progression of atherosclerosis. miRNAs expression is modulated by different stimuli involved in every stage of atherosclerosis and conversely miRNAs modulates several pathways implicated in plaque development such as cholesterol metabolism. miRNAs are involved in the regulation of key processes that contribute to skin fibrosis, including TGF-beta signaling, ECM deposition, fibroblast proliferation and differentiation, and epithelial to mesenchymal transition or transformation. Some miRNAs are profibrotic and their upregulation favors these processes contributing to fibrosis, while anti-fibrotic miRNAs inhibit these processes and may be reduced in fibrosis.

Keywords: Micro RNA, Atherosclerosis, Skin fibrosis, Fibroblast, Plaque

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2394-3726

Cite this article: Anusree, S., Navis, S., & Prasobh, G.R. (2020). Role of Micro RNA in Therapy of Atherosclerosis and Skin Fibrosis: A Review, Int. J. Phar.& Biomedi. Rese. 7(4), 6-16. doi: http://dx.doi.org/10.18782/2394-3726.1099