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International Journal of Pharmacy & Biomedical Research (IJPBR)
Year : 2020, Volume : 7, Issue : 2
First page : (37) Last page : (49)
Article doi: http://dx.doi.org/10.18782/2394-3726.1085

Antidepressant Activity of Flower Extract of Chrysanthemum indicum L. in Experimental Animal

Avani K. Shewale*, N. S. Naikwade, P. L. Ladda and Sudhir Patil
Appasaheb Birnale College of Pharmacy, Sangli. Dis- Sangli, Maharashtra, India 416 416
*Corresponding Author E-mail: avanishewale1222@gmail.com 
Received: 7.03.2020  |  Revised: 10.04.2020   |  Accepted: 14.04.2020 


ABSTRACT

Depression is the common symptom in todays scenario. The Ethanolic extract of Chrysanthemum indicum Linn (EECI) contains flavanoids compound which has shown therapeutic potential in neurological diseases. The stuidy was undertaken to evaluate antidepressant activity of EECI using Despair Swim Test (DST) & Tail Suspension Test (TST). The Swiss Albino mice weighing about 20-25 gm were used. The animals were divided into 4 groups, each group comprising of 6 animals,(n=6). Group I was control received Distilled Water (10ml/kg per oral), Group II Standard Imipramine HCl (10gm/kg per oral) and Group III & IV Test group, receives EECI (250 & 500 mg/kg per oral respectively).  All drugs were administered for 10 days. The results were analysed using one way ANOVA followed by Dunnetts test, p<0.05 was considered as significant. The effect of EECI on immobility periods of mice were assessed in DST & TST. The effect of EECI  were compared with that of control. The effect of 500mg/kg showed significant reduction in immobility time of mice in both DST & TST. The present study suggests that possible antidepressant activity of EECI in mice on the 500mg/kg drug administration is more than 250mg/kg.

Keywords: Chrysanthemum indicum Linn, Imipramine HCl, Despair Swim Test, Tail Suspension Test.

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2394-3726

Cite this article: Shewale, A.K., Naikwade, N.S., Ladda, P.L., & Patil, S. (2020). Antidepressant Activity of Flower Extract of Chrysanthemum indicum L. in Experimental Animal, Int. J. Phar.& Biomedi. Rese.7(2), 37-49. doi: http://dx.doi.org/10.18782/2394-3726.1085