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International Journal of Pharmacy & Biomedical Research (IJPBR)
Year : 2020, Volume : 7, Issue : 2
First page : (12) Last page : (24)
Article doi: http://dx.doi.org/10.18782/2394-3726.1087

Tumor Cell Immunotherapy: Current options and A New Insight in Veterinary Medicine

Tadelech Yilma1, Nigus Abebe1 and Haben Fesseha2*
1College of Veterinary Medicine, Mekele University, PO box 2084, Mekelle, Ethiopia
2School of Veterinary Medicine, Wolaita Sodo University, PO box 138, Wolaita Sodo, Ethiopia
*Corresponding Author E-mail: tseyon.h@gmail.com
Received: 4.03.2020  |  Revised: 16.04.2020   |  Accepted: 22.04.2020 


ABSTRACT

Tumor immunology describes the complex interaction between the host immune system and the antigens expressed by tumor cells. Tumor cells differ from normal cells by changes in the regulation of growth, allowing them to proliferate indefinitely and eventually metastasize to other tissues. Tumor cells can display tumor-specific antigens, which are novel proteins, and tumor-associated antigens, which are modified normal proteins or proteins with changed patterns of expression. Immunoediting describes the process by which developing the anti-tumor immune response both identifies and kills tumor cells, as well as participates in the selection of cells that have developed immuno evasive mutations. An intact immune system is essential to prevent the development and progression of neoplastic cells in a process termed as immune surveillance. Cancer immune-surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumor cells, three essential phases have been proposed: elimination, equilibrium, and escape. The innate and the adaptive immune systems closely cooperate and play an important role to detect and eliminate tumor cells. Furthermore, most cancers escape immuno-surveillance because they are fundamentally “self,” and auto-reactive immune cells are usually deleted or anergized. Therefore, a well thought out immunotherapy strategy would keep in mind, the escape mechanisms of the tumor could adopt under immune pressure to direct the most propitious strike. In this review, a general overview of tumor immunology, the basic principles of immunoediting, and the central role of immune effector cells in the process of immunoediting are discussed. Finally, Recommendations are forwarded.

Keywords: Cancer, Immunoediting, Immunotherapy, Tumor antigens

Full Text : PDF; Journal doi : http://dx.doi.org/10.18782/2394-3726

Cite this article: Yilma, T., Abebe, N., & Fesseha, H. (2020). Tumor Cell Immunotherapy: Current options and A New Insight in Veterinary Medicine, Int. J. Phar.& Biomedi. Rese.7(2), 12-24. doi: http://dx.doi.org/10.18782/2394-3726.1087